Ochinai Yogore wo Boku wa Nanto Yobeba Yokatta noka

This world is filthy… Nakayama, a high school boy with an extreme case of germophobia, avoids all social interaction and tries to enjoy his private time alone in a perfectly clean space. But his peaceful days are constantly disrupted by Nishino-san, the cheerful and unpredictable girl who ends up sitting next to him. "Don’t pollute my sanctuary! Don’t intrude on my time!" Contrary to his wishes, day after day, Nakayama is at Nishino's mercy in this chatty rom-com about a germophobe and an unsophisticated high school girl!!

(Source: Kadokawa, translated)
https://mechacomic.jp/books/251402