Hagane no Renkinjutsushi

From Viz:
Alchemy: the mystical power to alter the natural world, something between magic, art and science. When two brothers, Edward and Alphonse Elric, dabbled in this power to grant their dearest wish, one of them lost an arm and a leg and the other became nothing but a soul locked into a body of living steel. Now Edward is an agent of the government, a slave of the military-alchemical complex, using his unique powers to obey orders even to kill. Except his powers aren't unique. The world has been ravaged by the abuse of alchemy. And in pursuit of the ultimate alchemical treasure, the Philosopher's Stone, their enemies are even more ruthless than they are.

Note: Won the 49th Shogakukan Manga Award in the Shounen category in 2004 alongside [Yakitate!! Japan](/series/r2ag9dm/yakitate-japan), the 15th Tezuka Osamu Cultural Award New Artist Prize in 2011, the Eagle Award's Favourite Manga in 2010 and 2011, the Seiun Award for best science fiction comic in 2011. Nominated for the Grand Prize at the 10th Sense of Gender Award in 2010.